If you are knowledgeable in reading other’s cards that will help you more in playing your game easier. or if any folds in the first street itself will give you a idea of that they have two pairs or three of a kind. Usually holding Ace in the first round will not help you much but commonly players will raise or bet in this situations. But in the case of online games it is not possible to listen ones reactions and hence listen on their time to react for their next step.
One usual old psychology is players reacting weak are generally strong and those who react strong are generally weak or at least bluffing. Usually if you are in a draw for the first three rounds and it prolongs for the fourth street too then the best played way is to fold.
Handle the bluffing strategy in stud poker when your cards are cold or the antes are high. And more over, bluffing in the needed place will help you by confusing your opponents and they will not get an image on your way of playing. Even its not a best hand but good then you choose a semi bluffing. If you think that it is nothing but you have a advantage of playing then choose pure bluffing.